Which pharmacologic agent is supported by the best available evidence for managing excessive worry and tension?

Escitalopram (Lexapro) is supported by the best available evidence for managing excessive worry and tension, particularly in the context of generalized anxiety disorder (GAD). It is a selective serotonin reuptake inhibitor (SSRI) that has been shown to effectively reduce symptoms of anxiety, including excessive worry. Clinical studies consistently demonstrate that escitalopram provides significant improvements in anxiety symptoms, making it a first-line treatment option for GAD.

Moreover, escitalopram is well-tolerated by patients, which contributes to its favorable safety profile and makes it a preferred choice for many healthcare providers. Its efficacy in relieving tension and anxiety is backed by numerous clinical trials and guidelines, highlighting its importance in the pharmacological management of anxiety disorders.