Which of the following findings would classify a child’s lymphadenopathy as requiring antibiotic therapy?

The presence of unilateral lymphadenopathy with skin erythema and tenderness indicates an inflammatory process that is typically associated with infection. In this scenario, the swelling (lymphadenopathy) is localized to one side, suggesting that the body may be responding to a localized infection, such as cellulitis or an abscess, which often requires antibiotic treatment to address the underlying bacterial cause.

The signs of skin erythema and tenderness further support the diagnosis of an active infection, necessitating a more aggressive therapeutic approach like antibiotics. Prompt treatment is crucial to prevent complications that can arise from untreated infections, especially in children whose immune systems may be less robust.

In contrast, generalized lymphadenopathy in multiple areas could indicate systemic conditions that may not require antibiotics, while non-tender, firm lymph nodes often suggest a different etiology, perhaps even of a neoplastic nature, which would not be treated with antibiotics. Mild fever without other significant symptoms does not alone warrant antibiotic therapy, as it could result from a viral infection or transient response in the absence of bacterial involvement. Therefore, the characteristics outlined in the correct option are key indicators for initiating antibiotic treatment in cases of lymphadenopathy.