Which medication is the first-line treatment for pertussis?

Azithromycin is recognized as the first-line treatment for pertussis, also known as whooping cough, primarily due to its efficacy against the causative agent, Bordetella pertussis. Guidelines recommend this macrolide antibiotic for its effectiveness in shortening the duration of the illness, particularly if administered in the early stages of the infection.

The choice of azithromycin also stems from its favorable pharmacokinetic profile, including better gastrointestinal tolerance and a more convenient dosing schedule compared to other antibiotics. This allows for improved adherence to the treatment regimen, which is crucial in managing the infection and preventing its spread, especially in vulnerable populations, such as infants and young children.

Furthermore, azithromycin can also be administered to close contacts of infected individuals as a prophylactic measure, highlighting its role not only in treatment but also in controlling outbreaks. This makes it a comprehensive choice in the clinical management of pertussis, solidifying its position as the preferred first-line medication in practice.