What outcome has been demonstrated in randomized clinical trials concerning antioxidant supplementation?

Randomized clinical trials have shown that some antioxidant supplements can lead to increased mortality in certain populations. This finding suggests that while antioxidants might be perceived as beneficial for health due to their ability to neutralize free radicals, their supplementation, particularly in high doses or among specific groups, could have harmful effects.

For example, studies have indicated that supplements such as beta-carotene and vitamin E can be associated with higher rates of mortality, particularly in smokers or those at risk for specific diseases. This counterintuitive result highlights the complexity of nutritional supplementation and underscores the importance of relying on dietary sources of antioxidants rather than supplements, as whole foods often contain a balance of nutrients and phytochemicals that work synergistically.

Other options presented do not accurately reflect the consensus from clinical trial outcomes. While some may suggest improvements in specific areas of health or no notable effects at all, the clear and significant finding of increased mortality with specific antioxidant supplements stands out in the research. This calls for caution when it comes to supplementation without professional guidance.