What is the recommended dosage of aspirin for preeclampsia prevention in high-risk women?

The recommended dosage of aspirin for the prevention of preeclampsia in high-risk women is 81 mg per day. This dosage is supported by guidelines from various health organizations, which suggest that low-dose aspirin can significantly reduce the risk of developing preeclampsia in women who are identified as being at high risk due to factors such as previous preeclampsia, chronic hypertension, or certain medical conditions.

Research indicates that starting low-dose aspirin in the late first trimester is effective in this preventive role. The 81 mg dosage is both effective and considered safe for most pregnant women, balancing the need for efficacy in reducing the risk of preeclampsia while minimizing potential side effects. Higher doses, such as 100 mg or 150 mg, do not provide additional benefits in preventing preeclampsia and may increase the risk of side effects, making them less desirable options. Thus, the use of 81 mg daily is a well-established and evidence-based guideline for this specific scenario in maternal-fetal medicine.