What is the most appropriate treatment for a female with infertility and symptoms indicative of PCOS?

In the context of treating infertility in a female with symptoms indicative of polycystic ovary syndrome (PCOS), the use of Metformin is particularly relevant when insulin resistance is a contributing factor. PCOS often features metabolic issues, including insulin resistance, which can affect ovarian function and contribute to infertility.

Metformin addresses these metabolic concerns by improving insulin sensitivity, which can lead to more regular ovulatory cycles. By enhancing the hormonal environment, it indirectly supports fertility and can be beneficial for women with PCOS, especially in those who are overweight or obese.

In cases where lifestyle modifications alone are insufficient, Metformin is recognized for its effectiveness in managing the overall syndrome as well as helping to induce ovulation in some patients. It may also be used in conjunction with other fertility treatments, making it a foundational approach for those with PCOS experiencing infertility.

While Clomiphene citrate and Letrozole are also options for inducing ovulation, Metformin is geared more towards addressing the underlying metabolic dysfunction associated with PCOS. HCG injections are typically employed in later stages of the fertility process for triggering ovulation rather than treating the syndrome or addressing insulin resistance directly.