How can taking oral iron with vitamin C affect iron absorption?

Taking oral iron with vitamin C significantly increases iron absorption due to the synergistic effect between the two substances. Vitamin C, or ascorbic acid, enhances the solubility of ferrous iron (the more absorbable form of iron) in the gastrointestinal tract. When vitamin C is present, it reduces ferric iron (Fe3+) back to ferrous iron (Fe2+), which is more readily absorbed by the intestinal mucosa.

Additionally, vitamin C may help prevent the formation of insoluble iron complexes that can arise in the presence of certain dietary components, such as phytates or polyphenols, which can inhibit absorption. Thus, the combination of oral iron and vitamin C not only facilitates a more efficient uptake of iron but can also potentially improve overall iron bioavailability in the body. This enhanced absorption can be particularly beneficial for individuals with iron deficiency or those requiring additional iron supplementation.