During testosterone replacement therapy, which parameter should be monitored regularly?

Monitoring hematocrit during testosterone replacement therapy is essential due to the potential effect of testosterone on red blood cell production. Testosterone can stimulate erythropoiesis, leading to an increase in red blood cell mass. This increase can result in elevated hematocrit levels, which may raise the risk of thrombosis and other cardiovascular events if not managed appropriately.

Regular monitoring of hematocrit allows healthcare providers to identify any significant increases that may necessitate intervention, such as adjustments in therapy or phlebotomy to reduce hematocrit levels and mitigate potential complications. This aspect of monitoring is crucial in ensuring both the efficacy and safety of testosterone replacement therapy.

While monitoring blood glucose, liver function tests, and electrolyte balance may also be relevant in the overall management of a patient on testosterone therapy, they are not directly linked to the primary physiologic effects of testosterone replacement as it relates to erythropoiesis and hematocrit levels.